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Use in Lactation: Mercaptopuine has been detected in the breast milk of renal transplant patients purinethol price long term side effects of purinethol purinethol crohn's disease purinethol receiving immunosuppressive therapy with azathioprine, a pro-drug of mercaptopurine and thus mothers receiving PURI-NETHOL should not breast feed .
Vaccinations with live organism vaccines are not recommended in immunocompromised individuals (See purinethol PRECAUTIONS) .
Effect of concomitant drugs on purinethol PURI-NETHOL Ribavirin inhibits the enzyme, inosine monophosphate dehydrogenase (IMPDH), leading to a lower production of the active 6-thioguanine nucleotides .
Severe myelosuppression has been reported following concomitant administration of a pro-drug of mercaptopurine and ribavirin; therefore concomitant administration of purinethol ribavirin and PURI-NETHOL is not advised (see Myelosuppressive agents When PURI-NETHOL is combined with other myelosuppressive agents, caution should be used; dose reductions may be needed based on haematological monitoring (see Allopurinol/oxipurinol/thiopurinol Xanthine oxidase activity is inhibited by allopurinol, oxipurinol and thiopurinol, which results in reduced conversion of biologically active 6-thioinosinic acid to biologically inactive 6-thiouric When allopurinol, oxipurinol and/or thiopurinol and mercaptopurine are administered concomitantly it is essential that only a 25% of the usual dose of mercaptopurine is given (see DOSAGE AND ADMINISTRATION) since allopurinol decreases the rate of catabolism of PURI-NETHOL TABLETS – Product Information Aminosalicylates Inhibition of the anticoagulant effect of warfarin when given with mercaptopurine, has been There is in vitro and in vivo evidence that aminosalicylate derivatives (e .
olsalazine, mesalazine or sulphasalazine) inhibit the purinethol biverkningar purinethol gewichtstoename purinethol and milk purinethol smpc purinethol TPMT enzyme .
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